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  1. Vinyl chloride is a colorless gas that is used to make PVC, a hard plastic resin. It is also produced in tobacco smoke. Exposure to vinyl chloride can increase the risk of liver cancer and other cancers, especially in workers and the general population. Learn more about the sources, exposure limits, and references from NCI.

  2. 12 de jun. de 2023 · This activity will review the historical significance of vinyl chloride as an industrial carcinogen, the etiology of exposure, its toxicity and metabolism, acute and chronic complications of exposure, and their management.

  3. The primary target of vinyl chloride acute exposure is the CNS. Signs and symptoms include dizziness, ataxia, inebriation, fatigue, numbness and tingling of the extremities, visual disturbances, coma, and death.

  4. How can I be exposed to vinyl chloride? You can be exposed by breathing vinyl chloride that has been released from plastic manufacturing facilities, hazardous waste sites, and landfills. You can also be exposed from cigarette and cigar smoke.

  5. Our data suggest that even in the absence of high fat diet, exposure to vinyl chloride (0.8 ppm, 6h/day, 5day/week, for 12 weeks) induces glucose intolerance (1.0 g/kg, i.p) in male C57BL/6 mice. This was accompanied with the depletion of hepatic glutathione and a modest increase in lung interstitial macrophages.

  6. Sources and Potential Exposure. Ambient air concentrations of vinyl chloride are generally quite low, with exposure occurring from the discharge of exhaust gases from factories that manufacture or process vinyl chloride, or evaporation from areas where chemical wastes are stored. (2,3) .

  7. Vinyl chloride is a synthetic chemical used in PVC manufacturing and a component of cigarette smoke. Short-term exposure can cause irritation, dizziness, and headaches, while chronic exposure can increase the risk of liver cancer. Learn more about the structure, sources, symptoms, and treatment of vinyl chloride poisoning from Poison Control.