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The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These cell wall components are often directly involved in host–pathogen interaction and recognition, intracellular survival, and virulence.
The mycobacterial bacillus is encompassed by a remarkably elaborate cell wall structure. The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of Mycobacterium tuberculosis and maintains a robust basal structure supporting the upper “myco-membrane.”
7 de jul. de 2019 · Stokes RW, Norris-Jones R, Brooks DE, Beveridge TJ, Doxsee D and Thorson LM (2004) The glycan-rich outer layer of the cell wall of Mycobacterium tuberculosis acts as an antiphagocytic capsule limiting the association of the bacterium with macrophages.
Much of the early structural definition of the cell wall of Mycobacterium spp. was initiated in the 1960s and 1970s. There was a long period of inactivity, but more recent developments in NMR and mass spectral analysis and definition of the M. tuberculosis genome have resulted in a thorough understa ….
9 de oct. de 2017 · The plasma membranes (PM) and the native MM-containing cell walls (MMCW) of two rapid-growing mycobacterial species, Mycobacterium aurum and M. smegmatis, were isolated from their cell...
25 de abr. de 2023 · The Mycobacterium tuberculosis (Mtb) cell wall is probably the most complex membrane of all bacteria. The architecture of this complex wall extends to a massive core comprised of peptidoglycans covalently attached via a linker unit to a linear galactofuran and to several strands of a highly branched arabinofuran, and mycolic acids.
13 de feb. de 2023 · The mycolic acid layer of the Mycobacterium tuberculosis cell wall is essential for viability and virulence, and the enzymes responsible for its synthesis are targets for antimycobacterial drug...
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