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Cancer is basically a disease of uncontrolled cell division. Its development and progression are usually linked to a series of changes in the activity of cell cycle regulators. For example, inhibitors of the cell cycle keep cells from dividing when conditions aren’t right, so too little activity of these inhibitors can promote cancer.
10 de sept. de 2021 · This Review discusses our current understanding of cell cycle regulation, the functions of cell cycle checkpoints and how disruption of these finely tuned mechanisms is associated with...
17 de jun. de 2003 · CELL CYCLE AND CANCER. In cancer, there are fundamental alterations in the genetic control of cell division, resulting in an unrestrained cell proliferation. Mutations mainly occur in two classes of genes: proto‐oncogenes and tumour suppressor genes.
14 de ago. de 2023 · Overall, the cell cycle has many regulatory steps that are crucial to maintaining homeostasis inside of the cells during the replication of DNA and the division of cells. Mutation inside specific genes can lead to the loss of balance inside the cells, thus resulting in cancer growth.
1 de abr. de 1997 · Superficially, the connection between the cell cycle and cancer is obvious: cell cycle machinery controls cell proliferation, and cancer is a disease of inappropriate cell proliferation. Fundamentally, all cancers permit the existence of too many cells.
Cell cycle on the crossroad of tumorigenesis and cancer therapy. Trends Cell Biol. 2022 Jan;32 (1):30-44. doi: 10.1016/j.tcb.2021.07.001. Epub 2021 Jul 22. Authors. Jing Liu 1 , Yunhua Peng 1 , Wenyi Wei 2. Affiliations. 1 Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
3 de ene. de 2022 · Cell cycle machinery and its function in cancer. After the identification of first cell cycle regulator gene cdc28 (the analog of CDK1 in yeast) in early 1970s [ 1 ], the long history of cell cycle study reveals the mechanisms of how cell cycle functions as the fundamental event in cell biology [ 2, 3 ].
