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10 de sept. de 2021 · This Review discusses our current understanding of cell cycle regulation, the functions of cell cycle checkpoints and how disruption of these finely tuned mechanisms is associated with...
3 de ene. de 2022 · Cell cycle machinery and its function in cancer. After the identification of first cell cycle regulator gene cdc28 (the analog of CDK1 in yeast) in early 1970s [ 1 ], the long history of cell cycle study reveals the mechanisms of how cell cycle functions as the fundamental event in cell biology [ 2, 3 ].
17 de jun. de 2003 · CELL CYCLE AND CANCER. In cancer, there are fundamental alterations in the genetic control of cell division, resulting in an unrestrained cell proliferation. Mutations mainly occur in two classes of genes: proto‐oncogenes and tumour suppressor genes.
Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells.
Cell cycle on the crossroad of tumorigenesis and cancer therapy. Trends Cell Biol. 2022 Jan;32 (1):30-44. doi: 10.1016/j.tcb.2021.07.001. Epub 2021 Jul 22. Authors. Jing Liu 1 , Yunhua Peng 1 , Wenyi Wei 2. Affiliations. 1 Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
5 de ago. de 2022 · Mohammed Akhter Hossain & Kambiz Varmira. 3726 Accesses. 18 Citations. Explore all metrics. Abstract. The process of cell division plays a vital role in cancer progression. Cell proliferation and error-free chromosomes segregation during mitosis are central events in life cycle.
Cancer is basically a disease of uncontrolled cell division. Its development and progression are usually linked to a series of changes in the activity of cell cycle regulators. For example, inhibitors of the cell cycle keep cells from dividing when conditions aren’t right, so too little activity of these inhibitors can promote cancer.
