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  1. www.ncbi.nlm.nih.gov › pmc › articlesThe Changing Opioid Crisis: development, challenges and...

    While earlier phases (i.e., first wave) of the crisis were predominantly driven by non-medical use and addiction to prescription opioid analgesics, heroin (second wave) and subsequently illicit synthetic opioids (third wave) have become progressively important as the crisis progressed and more recently there is emerging evidence of increasing ...

  2. www.mayoclinic.org › in-depth › how-opioid-addiction-occursHow opioid use disorder occurs - Mayo Clinic

    29 de nov. de 2023 · Learn how opioids can trigger addiction and overdose, and what factors increase the risk of opioid misuse. Find out how to get help from your healthcare team if you're taking opioids for pain relief.

  3. www.thelancet.com › journals › lanamOpioid crisis: addiction, overprescription, and ... - The Lancet

    As a result, 60,000,000 people struggle with the addictive effects of opioids globally and more than 100,000 people die every year of opioid overdose, many of them with fentanyl, an analgesic drug that is 50–100 times more potent than heroin or morphine.

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  5. pubmed.ncbi.nlm.nih.gov › 33300384Relative addictive potential of opioid analgesic agents - PubMed

    While all opioid analgesic agents have some addictive potential, it is clear that there are some with greater addictive potential. Oxycodone is the most widely abused opioid analgesic and it appears to predispose to chronic use with high likability by users.

  6. www.tandfonline.com › doi › fullFull article: Opioid epidemic: lessons learned and updated ...

    20 de may. de 2022 · In this expert review, we discuss opioid (over)prescription, change in perception of pain, and false advertisement of opioid safety as the leading causes of the US opioid epidemic. Then, we review the evidence about opioid dependence and addiction potential and provide current knowledge about predictors of aberrant opioid-related ...