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18 de ene. de 2018 · During sterilization, gamma rays efficiently eliminate microorganisms from the medical devices and tissue allografts, but also significantly change molecular structure of irradiated products, particularly fragile biologics such as cytokines, chemokines and growth factors.
Around 12 million m3 of medical devices are sterilized by radiation annually. More than 40 per cent of all single-use medical devices produced worldwide are sterilized with gamma irradiation. The IAEA helps its Member States set up radiation facilities and provides guidelines for the use of sterilization applications that use radiation.
27 de feb. de 2018 · Gamma-ray irradiation at doses of ≥15 kGy was required for effective sterilization as evidenced by complete eradication of gram positive and negative bacteria. γ-PPy substrates also showed...
Sterility by gamma irradiation is achieved mainly by the alteration of nucleic acid and preventing the cellular division. This review focuses on the extensive application of gamma sterilization to a wide range of pharmaceutical components including active pharmaceutical ingredients, excipients, final drug products, and combination drug ...
18 de mar. de 2021 · Medical equipment, devices, and drugs are most commonly sterilized using gamma (γ)-irradiation. The main advantage of γ-irradiation is its high level of penetration and isothermal characteristics, which can appropriately manage heat-sensitive materials include inorganic metal oxides, polymer blends, or liquid crystals.
15 de sept. de 2020 · Gamma (γ) radiation is widely used to sterilize materials in a variety of settings. It is used in the food [ 1 ], pharmaceutical [ 2] and medical industries [ 3, 4] due to the ability of γ-radiation to inactivate pathogens through nucleic acid damage, whilst leaving proteins and other structures largely intact.
3 de jun. de 2021 · The two sterilization methods are comparable in terms of their sterilization principle (photons), with some technical advantage for X-ray regarding better dose uniformity and less oxidative stress for certain polymers. 3 Principally, any sterilization change could affect the final product safety and performance and therefore must be supported by...
