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3 de ene. de 2024 · RHOH (Ras Homolog Family Member H) is a Protein Coding gene. Diseases associated with RHOH include Epidermodysplasia Verruciformis 4 and Lymphoma. Among its related pathways are GPCR Pathway and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase inhibitor activity.
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20 de abr. de 2021 · Abstract. As an atypical member of the Rho family small GTPases, RhoH shares less than 50% sequence similarity with other members, and its expression is commonly observed in the haematopoietic lineage. To date, RhoH function was observed in regulating T cell receptor signalling, and less is known in other haematopoietic cells.
14 de oct. de 2016 · To investigate a potential role of RhoH in eosinophil differentiation in vivo, we analyzed the peripheral blood and bone marrow of RhoH −/− and wild-type (WT) mice, and found that absolute ...
5 de mar. de 2024 · RhoH is a key adapter protein that maintains LCK in the inactive state, contributing to the regulation of both pre-TCR and TCR signalling during T-cell development. propose that RhoH functions as a negative regulator for IL3-induced signals through modulation of the JAK-STAT pathway
21 de nov. de 2006 · RhoH is a small GTPase expressed only in the hematopoietic system. With the use of mice with targeted disruption of the RhoH gene, we demonstrated that RhoH is crucial for thymocyte maturation during DN3 to DN4 transition and
RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOH.