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El diagnóstico de demencia en enfermedad de Alzheimer aplicando los criterios del DSM-IV apoyados en una historia clínica que incluya un informante confiable y suplementados por una aproximación objetiva mediante tests cognitivos y evaluación neuropsicológica alcanzan un nivel de evidencia tipo II y un grado de recomendación clase B.
22 de abr. de 2015 · In this review, we discuss the availability of human post-mortem tissue through brain banks, the limitations associated with its use, the technical tools available, and the neuroimmune aspects to explore in order to validate in the human brain the experimental observations arising from animal models.
2 de ago. de 2019 · Clinical AD dementia cannot be definitively diagnosed until post-mortem neuropathologic evaluation, though research institutes capable of assessing amyloid and tau burden in living patients are challenging this historic paradigm .
15 de jun. de 2021 · ¿Cómo se diagnostica la enfermedad de Alzheimer? Lo cierto es que el diagnóstico definitivo solo se puede lograr mediante una prueba post mortem, es decir, a través de una autopsia cerebral. Sin embargo, en la actualidad existen una serie de métodos complementarios que permiten acercarnos a la confirmación con una seguridad ...
24 de mar. de 2022 · Increasing evidence from cohort studies of ageing and dementia suggests that not everyone who harbours plaques and tangles in the brain at post mortem had clinical symptoms of the disease...
1 de mar. de 2021 · At post-mortem there are cortical regions that range from mildly to severely affected by tau pathology and neuronal loss. A comparison of the molecular signatures of these differentially...
12 de dic. de 2017 · Abstract. Neuroinflammation is proposed as one of the mechanisms by which Alzheimer’s disease pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases in the...
