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Hace 1 día · Importance While β-blockers are associated with decreased mortality in cardiovascular disease (CVD), exacerbation-prone patients with chronic obstructive pulmonary disease (COPD) who received metoprolol in the Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (BLOCK-COPD) trial experienced increased risk of exacerbations requiring hospitalization.
Hace 2 días · Non-vasodilating beta-blockers, titrated to effectiveness or maximally tolerated doses, are the first-line therapy for symptomatic patients with oHCM (class IB recommendation) (1. ... Given the small sample size and short follow-up time of the VALOR-HCM trial, ...
Hace 3 días · Murine data suggest β-blockers may reduce mucus production and release, 4,5 whereas β-blockade could lead to up-regulation of receptor density in the lungs, resulting in improved response to β-agonists. 6 β-Blockers could also blunt resting tachycardia, thus improving cardiac performance and reducing shortness of breath.
Hace 5 días · The inception of beta blockers dates back to the 1960s when Sir James Black pioneered the discovery of propranolol, a non-selective beta-adrenergic receptor antagonist. This breakthrough marked a pivotal moment in medical history, the beginning of an era of beta-blockers and laying the foundation for subsequent drug development in this class. [1-2]
Hace 2 días · SAN DIEGO -- The beta-blocker bisoprolol did not improve exacerbations in chronic obstructive pulmonary disease (COPD) patients, a randomized clinical trial found. Exacerbations requiring ...
Hace 2 días · Blocking beta 2 receptors increases vascular resistance, which is not what you want to do in hypertension, but a vascular-selective drug will not increase vascular resistance and if the drug is also vasodilatory, vascular resistance will be reduced. Carvedilol is not beta 1 selective, it is nonselective, and it does not have this effect.
Hace 3 días · Beta blockers and calcium channel blockers: Stimulates the formation of adenyl cyclase causing intracellular increase in cycling AMP and enhanced glycogenolysis and elevated serum glucose concentration. Glucose (Dextrose 50%) Insulin reaction
