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Granuloma inguinale is a rare genital ulcerative disease caused by K. granulomatis. Diagnosis requires visualization of Donovan bodies on tissue crush preparation or biopsy. Treatment options include azithromycin, doxycycline, erythromycin, or trimethoprim-sulfamethoxazole.
The presence of Donovan bodies in the tissue sample confirms donovanosis. Donovan bodies are rod-shaped, oval organisms that can be seen in the cytoplasm of mononuclear phagocytes or histiocytes in tissue samples from patients with granuloma inguinale. They appear deep purple when stained with Wright's stain.
12 de mar. de 2023 · Donovan bodies are small, oval or rounded immobile cocci found inside macrophages of those affected. They acquire a deep purple color when stained with Wrights stain. In endemic areas, extragenital donovanosis can be a significant cause of lymphadenopathy in HIV patients.
1 de dic. de 2002 · Definitive diagnosis of donovanosis is often hindered by the early disappearance of Donovan bodies on tissue smears after the start of treatment. Furthermore, it is likely that a number of persistent ulcers in which pathogens were not identified could now be attributed to donovanosis by using PCR.
25 de oct. de 2021 · Granuloma inguinale is characterized by intracellular inclusions in macrophages referred to as Donovan bodies. Granuloma inguinale usually affects the skin and mucous membranes in the genital...
1 de jun. de 2014 · Large vacuolated / foamy macrophages / histiocytes with multiple intracytoplasmic organisms (bacteria are called Donovan bodies, not the histiocytes; have bacillary or coccobacillary appearance); Donovan bodies may be extracellular Acute and chronic granulation tissue, fibrosis (dermal and subcutaneous cicatricial) in late stages
29 de dic. de 2023 · Donovanosis is a sexually transmitted disease caused by Klebsiella granulomatis bacteria, which produces painless genital ulcers. Learn about the types, risk factors, complications, and antibiotic therapy of donovanosis, also known as granuloma inguinale.
