Resultado de búsqueda
16 de abr. de 2020 · GLUTs are divided into two structurally and functionally distinct types: (i) GLUTs, which operate by facilitated diffusion 1 , 2 ; and (ii) sodium–glucose cotransporters (SGLTs), which actively transport glucose against the concentration gradient by coupling with sodium 3 , 4 .
Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption.
INTRODUCTION. Sodium-glucose cotransporter (SGLT) activity mediates apical sodium and glucose transport across cell membranes. Cotransport is driven by active sodium extrusion by the basolateral sodium/potassium-ATPase, thus facilitating glucose uptake against an intracellular up-hill gradient.
The energy for active glucose transport is provided by the sodium gradient across the cell membrane, the Na + glucose cotransport hypothesis first proposed in 1960 by Crane. Since the cloning of SGLT1 in 1987, there have been advances in the genetics, molecular biology, biochemistry, biophysics, and structure of SGLTs.
8 de dic. de 2021 · Subsequently, coupled Na + /glucose transport was found to be mediated by sodium–glucose cotransporters 2, 3 (SGLTs). SGLTs are responsible for active glucose and galactose absorption in...
Subsequently, coupled Na + /glucose transport was found to be mediated by sodium-glucose cotransporters (SGLTs) 2, 3. SGLTs are responsible for active glucose and galactose absorption in the intestine and for glucose reabsorption in the kidney 4, and are targeted by multiple drugs to treat diabetes 5.
Na + /glucose cotransporters (SGLTs) are responsible for the “secondary-active” transport of glucose and other substrates across cellular membranes. They concentrate glucose inside the cell using electrochemical energy from the transmembrane Na + gradient, employing an alternating access cotransport mechanism.
