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17 de ago. de 2020 · Abstract. Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous characteristics. A simulation study demonstrated that attempts to categorize patients with a complex disease into more homogeneous subgroups could have more power to elucidate hidden heritability.
17 de ago. de 2020 · Shinichi Kuriyama. Translational Psychiatry 10, Article number: 290 ( 2020 ) Cite this article. 9355 Accesses. 20 Citations. 16 Altmetric. Metrics. Abstract. Autism spectrum disorder (ASD) has...
22 de abr. de 2019 · Request PDF | Clustering by phenotype and genome-wide association study in autism | Background Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous...
Abstract. Autism spectrum disorder (ASD) has clinically and genetically heterogeneous characteristics. Here, we show a two-step genome-wide association study (GWAS). In the first step, we observed no significant associations in a GWAS including 597 cases and 370 controls.
30 de nov. de 2019 · Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous characteristics. Here, we show a two-step genome-wide association study (GWAS). We used two datasets: one genotyped with the Illumina Human Omni2.5 (Omni2.5) in the discovery stage, and the other genotyped with the Illumina BeadChip 1Mv3 (1Mv3) in the replication stage.
22 de abr. de 2019 · Autism spectrum disorder (ASD) has clinically and genetically heterogeneous characteristics. Here, we show a two-step genome-wide association study (GWAS). In the first step, we observed no significant associations in a GWAS including 597 cases and 370 controls.
22 de abr. de 2019 · A holistic PheWAS-inspired method to identify meaningful associations between ASD phenotypes and genotypes found that clusters based on integrated genetic and phenotype data were more effective at identifying relevant genes than clusters constructed from phenotype information alone.
