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9 de may. de 2023 · Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, characterized by asthma, eosinophilia and...
14 de mar. de 2016 · Lung disease is a common feature of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitides, including granulomatosis with polyangiitis (Wegener's), eosinophilic granulomatosis with polyangiitis (Churg–Strauss) and microscopic polyangiitis.
Descripción general. La vasculitis es una inflamación de los vasos sanguíneos. La inflamación puede engrosar las paredes de dichos vasos, lo que reduce el ancho del conducto interior de estos. Si se restringe el flujo sanguíneo, los órganos y los tejidos pueden dañarse.
Asthma may precede the development of systemic vasculitis by up to 30 years; however, a shorter duration of asthma before the onset of vasculitis is associated with a poorer prognosis (a mean interval of 6.6 years between onset of asthma and vasculitis).
7 de feb. de 2024 · Overview. Churg-Strauss syndrome is a disorder marked by blood vessel inflammation. This inflammation can restrict blood flow to organs and tissues, sometimes permanently damaging them. This condition is also known as eosinophilic granulomatosis with polyangiitis (EGPA). Adult-onset asthma is the most common sign of Churg-Strauss syndrome.
Common clinical manifestations include asthma, peripheral eosinophilia, and peripheral neuropa-thy. Only 40% of patients produce detectable ANCA. The overall prevalence of EGPA in European populations has been estimated to range from 2 to 38 cases per million (1,3).
Asthma is one of the cardinal features of EGPA. Asthma symptoms may begin long before the onset of vasculitis – e.g., many years before any other symptoms of EGPA arise, and long before the diagnosis of EGPA is made. Other early symptoms/signs include nasal polyps and allergic rhinitis.
