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  1. Hace 14 horas · Prevalence. About 0.17% to 0.89% (pre-pandemic) [9] Myalgic encephalomyelitis/chronic fatigue syndrome ( ME/CFS) is a serious long-term illness. People with ME/CFS experience a profound fatigue that does not go away with rest, sleep issues and problems with memory or concentration. They are able to do much less than before they became ill.