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12 de jul. de 2023 · Here we apply this technology to generate high-confidence enhancer–promoter RNA interaction maps in six additional cell lines. Using these maps, we discover that 37.9% of the enhancer–promoter RNA...
6 de mar. de 2024 · The additional sequences (sequence B or C) were specifically designed for the annealing process with DNA oligos, which facilitated the incorporation of the RNA/DNA chimeric elements. Sequence B contains additional sequences that are shorter in length (21 base pairs (bp)), while sequence C has a longer sequence length (51 bp).
8 de jun. de 2024 · Here, we compared the accuracy of predictions of biologically relevant secondary structures of dozens of self-cleaving ribozyme sequences using seven in silico RNA folding prediction tools with tasks of varying complexity.
10 de abr. de 2023 · Short cytosine extensions reduced p53 activation and cytotoxicity in human pluripotent stem cells, and enhanced homology-directed repair while maintaining bi-allelic editing. Longer extensions...
16 de dic. de 2022 · Various sequences can function as splice sites (represented by sequence logos), their strength generally correlating with their potential to base pair with U2 or U1 snRNAs and with the length and...
20 de nov. de 2024 · Additional considerations undermine the notion of enhancer modularity or their compactness. While short regulatory segments usually drive spatially restricted expression, they are often found to have broad activity, targeting multiple tissues (2, 24, 25, 34–36).By contrast, single enhancers are sometimes insufficient to produce robust gene expression in a given tissue: The additive activity ...
1 de ago. de 2021 · Diversification of promoter sequences and structure motifs allows additional complexity to be brought to transcriptional regulation associated with specific cells, tissues, or biological processes, such as stress response and tissue development.
