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6 de mar. de 2018 · open access. Highlights. •. Accelerated evolution in terrestrial, aerial, marine, and subterranean mammals. •. Accelerated regions (ARs) uncover diverse putative functional elements. •. Elephant ARs reveal candidate mechanisms to decrease mutations and cancer risk. •. Human AR homologs indicate concordance between clinical and species’ phenotypes.
Human accelerated regions (HARs) are evolutionarily conserved sequences that acquired an unexpectedly high number of nucleotide substitutions in the human genome since divergence from our common ancestor with chimpanzees.
11 de feb. de 2023 · Transcription factor binding sites are frequently under accelerated evolution in primates. Xinru Zhang, Bohao Fang & Yi-Fei Huang. Nature Communications 14, Article number: 783 ( 2023 ) Cite...
1 de jun. de 2023 · Here, we investigated the evolutionary landscape of lineage-specific accelerated regions (LinARs) across 49 primate species. Genomic comparison with dense taxa sampling of primate species significantly improved LinAR detection accuracy and revealed many novel human LinARs associated with brain development or disease.
26 de jul. de 2009 · MAGE is also an accelerated evolution platform that permits the repeated introduction and maintenance of many neutral (or deleterious) mutations in the cell population.
25 de ene. de 2024 · Science. 26 Jan 2024. Directed evolution is a powerful strategy for engineering biomolecules. However, classical approaches to directed evolution usually rely on a repeated sequence of labor-intensive steps where genes encoding biomolecules of interest are diversified in vitro, then transformed into cells, expressed, and subjected to ...
14 de sept. de 2012 · Science. Conflict and 'boom-bust' explain humans' rapid evolution. 15 September 2012. Did conflict in part drive innovations seen in the Turkana boy from Kenya? By Paul Rincon. Science editor,...
