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6 de ago. de 2020 · Quantitative measurements of biomolecule associations are central to biological understanding and are needed to build and test predictive and mechanistic models.
6 de ago. de 2020 · Quantitative measurements of biomolecule associations are central to biological understanding and are needed to build and test predictive and mechanistic models.
16 de oct. de 2014 · Binding affinities of functional protein-protein interactions (PPIs) span more than nine orders of magnitude, from very weak and transient interactions observed frequently in signal transduction and membrane trafficking [1], [2] to very strong interactions exhibited by several enzyme-inhibitor complexes with binding affinities (K d) reaching 10 ...
29 de nov. de 2021 · This observation indicates that binding affinity is a more effective predictor of substrate specificity than k cat /K m. Our findings have important biological and medicinal implications warranting additional considerations for enzyme substrate and inhibitor discovery.
1 de jun. de 2017 · The data from these experimental techniques provide valuable information on important interactions which influence the affinity of protein–protein complexes, binding site residues at the interface and thermodynamic parameters for understanding the mechanism of protein–protein recognition at molecular level [ 1 ].
5 de ene. de 2022 · Every reaction has characteristic values of affinity and specificity. We quantify affinity—the strength of binding—using ΔG, the free energy change between the bound and free (unbound) states of the partners.
11 de nov. de 2020 · Metrics. Abstract. Antibodies are proteins working in our immune system with high affinity and specificity for target antigens, making them excellent tools for both biotherapeutic and...
