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The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These cell wall components are often directly involved in host–pathogen interaction and recognition, intracellular survival, and virulence.
The mycobacterial bacillus is encompassed by a remarkably elaborate cell wall structure. The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of Mycobacterium tuberculosis and maintains a robust basal structure supporting the upper “myco-membrane.”
7 de jul. de 2019 · Stokes RW, Norris-Jones R, Brooks DE, Beveridge TJ, Doxsee D and Thorson LM (2004) The glycan-rich outer layer of the cell wall of Mycobacterium tuberculosis acts as an antiphagocytic capsule limiting the association of the bacterium with macrophages.
17 de may. de 2023 · The cell wall of Mycobacterium is a complex structure associated with intrinsic resistance to clearance in infected cells with the lipid barrier functioning as a shield in harsh environments . The composition of the cell wall and hydrophobicity confer low permeability .
Much of the early structural definition of the cell wall of Mycobacterium spp. was initiated in the 1960s and 1970s. There was a long period of inactivity, but more recent developments in NMR and mass spectral analysis and definition of the M. tuberculosis genome have resulted in a thorough understa ….
25 de abr. de 2023 · The Mycobacterium tuberculosis (Mtb) cell wall is probably the most complex membrane of all bacteria. The architecture of this complex wall extends to a massive core comprised of peptidoglycans covalently attached via a linker unit to a linear galactofuran and to several strands of a highly branched arabinofuran, and mycolic acids.
2 de sept. de 2016 · The unique cell wall of mycobacteria is essential to their viability and the target of many clinically used anti-tuberculosis drugs and inhibitors under development.
