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Cancer is basically a disease of uncontrolled cell division. Its development and progression are usually linked to a series of changes in the activity of cell cycle regulators. For example, inhibitors of the cell cycle keep cells from dividing when conditions aren’t right, so too little activity of these inhibitors can promote cancer.
10 de sept. de 2021 · This Review discusses our current understanding of cell cycle regulation, the functions of cell cycle checkpoints and how disruption of these finely tuned mechanisms is associated with...
14 de ago. de 2023 · Overall, the cell cycle has many regulatory steps that are crucial to maintaining homeostasis inside of the cells during the replication of DNA and the division of cells. Mutation inside specific genes can lead to the loss of balance inside the cells, thus resulting in cancer growth.
17 de jun. de 2003 · The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer - PMC. Journal List. Cell Prolif. v.36 (3); 2003 Jun. PMC6496723. As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health.
Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells.
Cell cycle on the crossroad of tumorigenesis and cancer therapy. Trends Cell Biol. 2022 Jan;32 (1):30-44. doi: 10.1016/j.tcb.2021.07.001. Epub 2021 Jul 22. Authors. Jing Liu 1 , Yunhua Peng 1 , Wenyi Wei 2. Affiliations. 1 Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
12 de oct. de 2011 · PDF. Tools. Share. Abstract. Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes cancer and loss of cell cycle checkpoint control promotes genetic instability.
