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Acetylcholine hydrolyzing enzyme acetylcholinesterase (AChE) belongs to the GDSL lipase/acylhydrolase protein family and has been found in several plant species. Several studies have demonstrated that GDSL members are involved in growth, development, and abiotic stress.
The solanaceous glycoalkaloids (SGAs) are naturally occurring steroids in potatoes and related plants that inhibit both acetylcholinesterase and butyrylcholinesterase. There are many clinical examples of direct SGA toxicity due to cholinesterase inhibition.
18 de oct. de 2022 · The approximate lethal dose of solanine for humans is 2 – 5 mg/kg [15, 80]. Lower concentrations of solanine are toxic for humans. The compound (but not solanidine) inhibits acetylcholinesterase, destroys the integrity of cell membranes, and lowers the membrane potential and transport of Ca ions .
1 de ago. de 2021 · Results indicated that alpha-solanine had the best fit into the AChE1 binding pocket with a minimum binding energy of −8.13 kJ/mol. Among the different alkaloids tested, it is suggested that alpha-solanine would serve as the best inhibitor of AChE1 in Ae. aegypti.
15 de jun. de 2024 · The study examined complexes of 3LII (Acetylcholinesterase receptor) in the A and B chain with Solanine and Rivastigmine derivatives, using an in-silico approach. PyRx default sorter was used to improve docking accuracy.
Seven solanaceous glycoalkaloids (α-chaconine, β2-chaconine, α-solanine, dehydrocommersonine, commersonine, demissine and tomatine) and three alkaloids (solanidine, tomatidine and demissidine) were tested for their ability to inhibit acetyl cholinesterase in anin vitro system.
Glycoalkaloid toxicity has been shown to inhibit acetylcholinesterase activity in the central nervous system, disrupt membrane integrity affect the digestive system and overall body metabolism, and cause birth defects.[21,22] In vitro experiments have observed that α-solanine and α-chaconine are potent cytotoxins that rapidly induce cell lysis.
