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2 de jun. de 2022 · A genome-wide association study of autism using the Simons Simplex Collection: does reducing phenotypic heterogeneity in autism increase genetic homogeneity? Biol. Psychiatry 77 , 775–784 (2015).
GWAS exploits the phenomenon of linkage disequilibrium (LD) to identify QTLs/genomic regions controlling a target trait. In this approach, QTLs and genomic regions controlling a target trait are identified based on the strength of correlation between thousands of genome-wide markers and the targeted phenotype (Mackay & Powell, 2007).In fact, association mapping, like QTL mapping, also assumes ...
30 de nov. de 2014 · Introduction. Genome-wide association study (GWAS) refers to study in which hundreds of thousands of single nucleotide polymorphisms (SNPs) are genotyped across the genome and tested for association with the phenotype of interest. In the past few years, numerous genetic susceptibility loci have been identified to be associated with many complex ...
MHC-histone cluster NRGN TCF4 ZNF804A: 47,536 47,536 47,536 47,536 ... Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 ... Dissecting the phenotype in genome-wide association studies of psychiatric illness ...
23 de oct. de 2021 · Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145):661–678 Google Scholar
5 de jul. de 2020 · A genome-wide association study of autism incorporating autism diagnostic interview-revised, autism diagnostic observation schedule, and social responsiveness scale. Child Dev. 84 , 17–33 (2013).
11 de jun. de 2018 · Although several genetic variants for autism spectrum disorder (ASD) have now been identified, these largely occur sporadically or are de novo. Much less progress has been made in identifying inherited variants, even though the disorder itself is familial in the majority of cases. The objective of this study was to identify chromosomal regions that harbor inherited variants increasing the risk ...
