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10 de nov. de 2009 · The structure of recombinant domain III of the envelope protein (rED3) of yellow fever virus (YFV), containing the major neutralization site, was determined using NMR spectroscopy. The amino acid sequence and structure of the YFV-rED3 shows differences from ED3s of other mosquito-borne flaviviruses; in particular, the partially ...
- Yellow Fever: A Reemerging Threat - PMC - National Center for ...
Fig. 3. The yellow fever virus genome. The genome is a...
- Structure-Function of the Yellow Fever Virus Envelope Protein: Analysis ...
This makes the WT-vaccine pair ideal candidates to study the...
- Yellow Fever: A Reemerging Threat - PMC - National Center for ...
Fig. 3. The yellow fever virus genome. The genome is a single-stranded RNA molecule of positive polarity (ie, can be translated), with highly structured 5′ and 3′ nontranslated regions, a 5′ terminal cap, and a single open reading frame encoding the 10 viral proteins, 3 structural and 7 nonstructural.
This makes the WT-vaccine pair ideal candidates to study the structure-function relationship of the E protein in the attenuation and immunogenicity of flaviviruses. In this study, we provide an overview of structure-function of YFV E protein and its involvement in protective immunity.
14 de may. de 2012 · Abstract. The yellow fever virus (YFV), the first proven human-pathogenic virus, although isolated in 1927, is still a major public health problem, especially in West Africa where it causes outbreaks every year.
24 de jun. de 2022 · The YFV genome is composed of a single-stranded RNA, plus sense, with near 11 Kb; the entire genome encodes a polyprotein containing ten genes, giving rise to three structural proteins, capsid (C), glycoprotein precursor of M protein (PrM)/membrane (M) protein, and envelope (E), and seven non-structural proteins (NS), named NS1, NS2A, NS2B, NS3,...
In the Americas, YFV transmission occurs mainly via the sylvatic cycle, in which nonhuman primates (NHPs) are infected by tree-dwelling mosquito vectors such as Haemagogus spp. and Sabethes spp. ( 10, 11). YFV transmission can also occur via an urban cycle, in which humans are infected by Aedes spp. mosquitoes that feed mostly on humans ( 12, 13 ).
23 de mar. de 2022 · Abstract. The envelope (E) protein of flaviviruses is functionally associated with viral tissue tropism and pathogenicity. For yellow fever virus (YFV), viscerotropic disease primarily...
