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24 de abr. de 2023 · Carbon dioxide, urea, uric acid, and creatinine are disposed into the maternal blood from the fetal circulation. Maternal blood contains IgG antibodies which diffuse through the placenta and provide naturally acquired passive immunity to the infant during the crucial first few months of life.
Placental cells (trophoblasts) invade both into the tissue of the uterus and into the maternal blood vessels nearest to the site of implantation (the spiral arteries (SAs)) and transform these allowing a relatively high and steady flow of nutrient-rich blood to perfuse the placenta.
The placenta is a unique vascular organ that receives blood supplies from both the maternal and the fetal systems and thus has two separate circulatory systems for blood: (1) the maternal-placental (uteroplacental) blood circulation, and (2) the fetal-placental (fetoplacental) blood circulation.
Non-invasive prenatal test (NIPT) is a screening method that identifies pregnant women with a high aneuploidy risk, specifically for trisomy 21, 18, 13, and chromosome X anomalies. NIPT analyzes free fetal DNA found in maternal blood. In this review, we describe the benefits, disadvantages and study indications.
Maternal blood is an ideal system for studying methylation changes and development of disease biomarkers, whereas fetal origin tissues like cord blood, cord tissue and placenta are good sources to study the deeper biological and molecular aspects of disease development.
25 de may. de 2023 · Fetal circulation, unlike postnatal circulation, involves the umbilical cord and placental blood vessels which carry fetal blood between the fetus and the placenta.
17 de dic. de 2020 · Fetal cells can pass into maternal blood in significant amounts during or after spontaneous miscarriage ( 8, 9 ). Fetomaternal hemorrhage after first trimester termination of pregnancy results in an 80-fold increase in fetal cells in maternal blood ( 10 ).
