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3 de jun. de 2022 · Mechanisms of High-Altitude Erythrocytosis. Hypoxemia, or low blood P o2, stimulates erythropoiesis. Although increased hematocrit and [Hb] values are observed in high-altitude populations, “normal” values vary greatly and depend on unique adaptations as well as the altitude of residence.
13 de oct. de 2016 · It takes weeks to produce new red blood cells, and even ordinary people can adapt within days. Now, the new study—the first to look closely at the blood of people trekking up and down mountains—has found that the body begins adapting to elevation as soon as overnight.
7 de oct. de 2016 · Here we applied metabolomics technologies to investigate the metabolic adaptation of human RBCs to high altitude hypoxia.
31 de dic. de 2007 · Here we review several case studies of Hb adaptation to hypoxia in high altitude vertebrates. Specifically, we highlight several case studies involving endothermic and ectothermic vertebrates where it has been possible to identify specific mechanisms of Hb adaptation.
4 de mar. de 2021 · Below I review and synthesize results from recent studies that illustrate how genomic data can be integrated with experimental physiology to yield insights into mechanisms of high-altitude adaptation.
7 de oct. de 2016 · Immediate metabolic adaptations were noted as early as a few hours from ascending to >5000 m, and maintained for 16 days at high altitude. Consistent with the mechanisms elucidated in vitro, hypoxia promoted glycolysis and deregulated the pentose phosphate pathway, as well purine catabolism, glutathione homeostasis, arginine/nitric ...
1 de jul. de 2022 · Although a modest increase in blood O 2-carrying capacity may be beneficial for life in highland environments, erythrocytosis can also become excessive and lead to maladaptive syndromes such as chronic mountain sickness (CMS).
