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27 de oct. de 2020 · NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of modified chromatin decorated with bactericidal proteins from granules and cytoplasm. Various pathogens, antibodies and immune complexes, cytokines, microcrystals, and other physiological stimuli can cause NETosis.
Apariencia. ocultar. Las trampas extracelulares de neutrófilos o NETs son una malla de ADN que encierra histonas y proteínas antimicrobianas, liberadas por los neutrófilos al espacio extracelular. Estas trampas extracelulares inmovilizan a los microbios, atrapándolos entre agentes antimicrobianos, como mieloperoxidasa, elastasa, proteinasa ...
Introducción. Los neutrófilos son células con núcleo lobulado (dos a cinco lóbulos) que tienen la capacidad fagocítica y parte integral de la respuesta inmune innata. Estas células reciben su nombre debido a que no se tiñen de manera regular con colorantes ácidos o básicos.
NET activation and release, or NETosis, is a dynamic process that can come in two forms, suicidal and vital NETosis. Overall, many of the key components of the process are similar for both types of NETosis, however, there are key differences in stimuli, timing, and ultimate result.
9 de oct. de 2017 · Neutrophil extracellular traps (NETs) cause pathology in a number of conditions through several mechanisms. Direct cell damage is implicated in infection, sepsis, autoimmunity and diabetes. By ...
6 de oct. de 2020 · In this review, we describe and discuss our current knowledge of the molecular, cellular, and biophysical mechanisms mediating NET release as well as open questions in the field. Keywords: PAD4; cell biology; cytoskeleton; innate immunity; neutrophil; neutrophil extracellular trap; nucleus.
23 de mar. de 2018 · NETosis is a regulated form of neutrophil cell death that contributes to the host defense against pathogens and was linked to various diseases soon after its first description in 2004.
