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Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer's patches, and the spleen – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at ...
4 de mar. de 2020 · Targeting immunometabolism during the germinal center response may afford the possibility to improve vaccine design and to develop new therapies to alleviate autoimmunity.
26 de abr. de 2022 · Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification and affinity-driven selection of immunoglobulins that produces the high-affinity antibodies essential for effective ….
Germinal centres are the main source of memory B cells and plasma cells that produce high-affinity antibodies in the body. In this Review, Ulf Klein and Riccardo Dalla-Favera describe the ...
6 de feb. de 2015 · The germinal centre (GC) of lymphoid organs is the microenvironment in which antigen-activated B cells diversify their immunoglobulin genes by somatic hypermutation (SHM) to generate...
25 de oct. de 2018 · The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection.
31 de mar. de 2021 · Germinal Center Initiation. Activation of naïve B cells in primary follicles induces migration to interfollicular areas and conjugates with antigen-specific T cells. B cells then present antigens to T cells and receive help through CD40-CD40L signals that promote B cell survival (5, 17, 18).
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