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  1. cima.cun.es › actualidad › noticiasUn neurobiólogo de EE. UU. cuestiona dogmas del Alzheimer

    Hoy se acepta como dogma que el aumento en la formación de dos proteínas, la beta-amiloide y la tau fosforilada, es determinante para la lesión de ciertos grupos neuronales del cerebro y de la consiguiente pérdida de capacidad mental que caracteriza a la enfermedad de Alzheimer. El Dr. Mark A. Smith, del Instituto de Patología de la Case ...

    • Enfermedades

      Conjunto de enfermedades que se investigan de forma...

  2. en.wikipedia.org › wiki › Mark_AMark A. Smith - Wikipedia

    He is recognized in the field of Alzheimer's disease research particularly for his work on oxidative stress, mitochondria dysfunction and cell cycle re-entry and, with a h-index of 73 and over 800 peer-review articles and reviews that have received over 21,000 citations, he was named as one of the top Alzheimer's disease researchers ...

  3. academic.oup.com › jnen › articleMark A. Smith, PhD: Renegade Scientist and Visionary

    1 de jun. de 2011 · The same cannot be said for Mark A. Smith, PhD, who died at the young age of 45 on December 19, 2010, 95 years to the day, as it would happen, after the death of Alois Alzheimer, the namesake for the condition that Mark would ultimately redefine.

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  5. www.ncbi.nlm.nih.gov › pmc › articlesMark A. Smith: The Scientist, the Man - PMC - National Center for...

    Alzheimer disease (AD) research suffered a devastating loss with the death of Mark A. Smith on 19 December 2010. In addition to being the most prolific and fifth most cited AD author, Mark had a keen eye for innovation and quality of execution.

  6. link.springer.com › article › 10Mark Smith: Pioneer of Alzheimer Disease Research

    27 de jul. de 2012 · Mark defined the first oxidative modifications found in AD and pioneered the foundation for cell cycle alteration and metabolic changes. He was also known for questioning the amyloid cascade hypothesis, providing evidence that amyloid-β (Aβ) and tau are protective responses to brain injury.

  7. www.j-alz.com › marksmithIn Memory: Mark A. Smith | Journal of Alzheimer's Disease

    Mark is recognized in the field of Alzheimer's disease research particularly for his work on oxidative stress, mitochondria dysfunction and cell cycle re-entry and, with a h-index of 73 and over 800 peer-review articles and reviews that have received over 21,000 citations.

  8. pubmed.ncbi.nlm.nih.gov › 17142016Alzheimer disease, the two-hit hypothesis: an update - PubMed

    Epub 2006 Oct 27. Authors. Xiongwei Zhu 1 , Hyoung-gon Lee , George Perry , Mark A Smith. Affiliation. 1 Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA. xiongwei.zhu@case.edu. PMID: 17142016. DOI: 10.1016/j.bbadis.2006.10.014. Abstract.