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16 de abr. de 2020 · GLUTs are divided into two structurally and functionally distinct types: (i) GLUTs, which operate by facilitated diffusion 1 , 2 ; and (ii) sodium–glucose cotransporters (SGLTs), which actively transport glucose against the concentration gradient by coupling with sodium 3 , 4 .
INTRODUCTION. Sodium-glucose cotransporter (SGLT) activity mediates apical sodium and glucose transport across cell membranes. Cotransport is driven by active sodium extrusion by the basolateral sodium/potassium-ATPase, thus facilitating glucose uptake against an intracellular up-hill gradient.
The low-affinity SGLT transporter had an apparent coupling stoichiometry of 1 Na:1 sugar, whereas for the high-affinity transporter, it was 2 Na:1 sugar. The low-affinity transporter became to be known as SGLT2, and the high-affinity transporter was determined to be SGLT1 .
SGLT2 and SGLT1 transport Na + and glucose with a Na +-glucose coupling ratio of 1:1 and 2:1, respectively . This enhances the glucose concentration power of SGLT1 and thereby the ability of the late proximal tubule to reabsorb glucose in the face of falling luminal glucose delivery ( Fig. 1 ).
8 de dic. de 2021 · SGLT1, the first member of the large sodium–solute symporter (SSS) family 2 to be identified, is a high-affinity, low-capacity glucose transporter with an apparent 2 Na +:1 sugar coupling ...
15 de ago. de 2014 · The model includes apical SGLT1 (the glucose sodium cotransporter), coupled apical flow of Na + and Cl −, basolateral Na-K-ATPase (the sodium potassium pump), basolateral GLUT2 (the facilitated glucose transporter), and diffusive flows of the three included ionic species: Na +, K +, and Cl − (see Fig. 1 ).
28 de feb. de 2024 · Here we discuss and compare the Na + - and H + -coupling mechanisms that drive substrate translocation. We highlight examples of strict and flexible ion coupling and allosteric ion-mediated...
