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  1. www.ncbi.nlm.nih.gov › pmc › articlesAntiviral Actions of Interferons

    The IFN system includes cells that synthesize IFN in response to an external stimulus such as viral infection and cells that respond to IFN by establishing an antiviral state ( 318, 351, 394 ). Animal viruses are inducers of IFN, and are also sensitive to the antiviral actions of IFNs.

    • PubMed

      At the interface between the innate and adaptive immune...

  2. www.nature.com › articles › nri888Viruses and interferon: a fight for supremacy - Nature

    1 de sept. de 2002 · Key Points. Interferons (IFNs) — the body's first line of antiviral defence — are cytokines that are secreted by host cells in response to virus infection. By inducing the expression of...

  3. www.ncbi.nlm.nih.gov › pmc › articlesImmunomodulatory Role of Interferons in Viral and Bacterial...

    14 de jun. de 2023 · In the 1960s and 1970s, researchers discovered that interferons are proteins that have antiviral activity and can protect neighboring cells from viral replication. In the 1980s, researchers learned more about the structure and function of interferons thanks to protein isolation and purification methods.

  4. www.ncbi.nlm.nih.gov › pmc › articlesDirect Antiviral Mechanisms of Interferon-Gamma - PMC

    17 de oct. de 2018 · Interferon-gamma (IFNG) was first discovered as a soluble macromolecule with antiviral activity ( 1 ). In contrast to virally induced interferon (IFN) ( 2 ), it was produced from leukocytes upon stimulation with phytohemagglutinin, a mitogenic plant lectin ( 1 ).

  5. www.nature.com › articles › s41564/019/0421-xDecoding type I and III interferon signalling during viral...

    1 de abr. de 2019 · Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors....

  6. pubmed.ncbi.nlm.nih.gov › 11585785Antiviral actions of interferons - PubMed

    PMID: 11585785. PMCID: PMC89003. DOI: 10.1128/CMR.14.4.778-809.2001. Abstract. Tremendous progress has been made in understanding the molecular basis of the antiviral actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the actions of IFNs.

  7. www.nature.com › articles › nri2314Interferon-inducible antiviral effectors | Nature Reviews...

    The action of the interferons (IFNs) is mediated through three receptor complexes: a heterodimer of IFNα receptor 1 (IFNAR1) and IFNAR2 binds type I IFNs; the interleukin-10 receptor 2 (IL-10R2)...