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The Cell-Cycle Control System Triggers the Major Processes of the Cell Cycle; The Control System Can Arrest the Cell Cycle at Specific Checkpoints; Checkpoints Generally Operate Through Negative Intracellular Signals; The Cell-Cycle Control System Is Based on Cyclically Activated Protein Kinases
Learn how the cell cycle is regulated by internal checkpoints and external signals, and how positive and negative regulators influence the progression of the cell cycle. Explore the roles of cyclins, Cdks, p53, Rb, and p21 in cell cycle control and their involvement in cancer.
10 de sept. de 2021 · 103 Altmetric. Metrics. Abstract. Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell...
Para evitar que una célula comprometida continúe dividiéndose, existen mecanismos de control interno que operan en tres puntos de control del ciclo celular principal en los que se puede detener el ciclo celular hasta que las condiciones sean favorables.
Un punto de control es una etapa en el ciclo celular eucarionte en la cual la célula examina las señales internas y externas, y “decide” si seguir adelante con la división o no. Hay varios puntos de control, pero los tres más importantes son: El punto de control G 1. , en la transición G 1. /S. El punto de control G 2. , en la transición G 2. /M.
8 de jun. de 2022 · 29 Citations. 84 Altmetric. Metrics. Cyclin-dependent kinases (CDKs) lie at the heart of eukaryotic cell cycle control, with different cyclin–CDK complexes initiating DNA replication...
Learn how cyclins, Cdks, and the APC/C control the events and transitions of the cell cycle. See how they work together, how they are regulated, and how they are conserved across species.
