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  1. www.nature.com › articles › s41418/022/00988-zCell cycle regulation: p53-p21-RB signaling - Nature

    31 de mar. de 2022 · Facts. The tumor suppressor p53 can induce cell cycle arrest. Induction of p53 leads to transcriptional downregulation of many cell cycle genes. The cyclin-dependent kinase inhibitor...

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  2. www.nature.com › articles › s41392/023/01347-1Targeting p53 pathways: mechanisms, structures, and advances in...

    1 de mar. de 2023 · The gene encoding p21 (CDKN1A) is the first transcriptional target identified for p53. 55 p21 is a potent inhibitor of binding to cyclin-dependent kinases (CDKs), which inhibits cell cycle ...

  3. www.nature.com › articles › s42003/023/05585-5p53 and p21 dynamics encode single-cell DNA damage levels ... -...

    24 de nov. de 2023 · Long-term p21 and p53 dynamics regulate the frequency of mitosis events and cell cycle arrest following radiation damage. Article 01 October 2022. p53 dynamics in single cells are...

  4. www.ncbi.nlm.nih.gov › pmc › articlesRole of p53 in the Regulation of Cellular Senescence - PMC

    8 de mar. de 2020 · The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity.

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  6. pubmed.ncbi.nlm.nih.gov › 35361964Cell cycle regulation: p53-p21-RB signaling - PubMed

    The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both proteins play central roles in regulating the cell division cycle. RB forms complexes with the E2F family of transcription factors and downregulates numerous genes.

  7. www.ncbi.nlm.nih.gov › pmc › articlesTumor Suppressor p53: Biology, Signaling Pathways, and...

    23 de feb. de 2022 · TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [ 1 ]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles in development, aging and cell differentiation [ 2 ].

  8. pubmed.ncbi.nlm.nih.gov › 27156098Multiple functions of p21 in cell cycle, apoptosis and ... -...

    Cyclin-dependent kinase (CDK) inhibitor p21 (also known as p21 (WAF1/Cip1)) is one of these factors that promote cell cycle arrest in response to a variety of stimuli. The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms.

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