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Hoy se acepta como dogma que el aumento en la formación de dos proteínas, la beta-amiloide y la tau fosforilada, es determinante para la lesión de ciertos grupos neuronales del cerebro y de la consiguiente pérdida de capacidad mental que caracteriza a la enfermedad de Alzheimer. El Dr. Mark A. Smith, del Instituto de Patología de la Case ...
- Enfermedades
Conjunto de enfermedades que se investigan de forma...
- Enfermedades
He is recognized in the field of Alzheimer's disease research particularly for his work on oxidative stress, mitochondria dysfunction and cell cycle re-entry and, with a h-index of 73 and over 800 peer-review articles and reviews that have received over 21,000 citations, he was named as one of the top Alzheimer's disease researchers ...
1 de jun. de 2011 · He also understood that oxidative stress was not an end but an opening into the beginning of Alzheimer disease. As such, Mark was also the first to crystallize the role of cell cycle activation as a basic mechanism of cellular pathophysiology within the brain and the 2-hit hypothesis involving oxidative injury and cell cycle reentry ...
27 de jul. de 2012 · Mark defined the first oxidative modifications found in AD and pioneered the foundation for cell cycle alteration and metabolic changes. He was also known for questioning the amyloid cascade hypothesis, providing evidence that amyloid-β (Aβ) and tau are protective responses to brain injury.
Alzheimer disease (AD) research suffered a devastating loss with the death of Mark A. Smith on 19 December 2010. In addition to being the most prolific and fifth most cited AD author, Mark had a keen eye for innovation and quality of execution.
Epub 2006 Oct 27. Authors. Xiongwei Zhu 1 , Hyoung-gon Lee , George Perry , Mark A Smith. Affiliation. 1 Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA. xiongwei.zhu@case.edu. PMID: 17142016. DOI: 10.1016/j.bbadis.2006.10.014. Abstract.
Mark is recognized in the field of Alzheimer's disease research particularly for his work on oxidative stress, mitochondria dysfunction and cell cycle re-entry and, with a h-index of 73 and over 800 peer-review articles and reviews that have received over 21,000 citations.
