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Martin Reijnders (born 11 April 1972) is a Dutch former professional footballer who played as a forward in the Netherlands, Finland and the United States. Career. Reijnders began his career with PEC Zwolle, graduating from the club's U19 team to the first team in 1990.
Postdoc @ LMU Munich - Cited by 631 - Chemical Biology
Martin Reynders's 32 research works with 622 citations and 2,085 reads, including: Photoactivated Protein Degrader for Optical Control of Synaptic Function
21 de feb. de 2020 · Abstract. PROTACs (PROteolysis TArgeting Chimeras) are bifunctional molecules that target proteins for ubiquitylation by an E3 ligase complex and subsequent degradation by the proteasome. They have emerged as powerful tools to control the levels of specific cellular proteins.
Martin Reynders1,2, Bryan S. Matsuura1, Marleen Bérouti1,2, Daniele Simoneschi3,4, Antonio Marzio3,4, Michele Pagano3,4,5*, Dirk Trauner1,4,6* PROTACs (PROteolysis TArgeting Chimeras) are bifunctional molecules that target proteins for ubiquitylation by an E3 ligase complex and subsequent degradation by the proteasome.
The optical control of protein degradation could be extended to E3 ubiquitin ligases beyond those containing CRBN and VHL, such as DCAF15 (Li et al., 2020), DCAF16 (Zhang et al., 2019a), RNF4 (Ward et al., 2019), and RNF114 (Spradlin et al., 2019). Ligands have been identified for these enzymes that could be caged or equipped with photoswitches.
3 de jun. de 2021 · Martin Reynders, Dr. Apirat Chaikuad, Dr. Benedict-Tilman Berger, Katharina Bauer, Prof. Dr. Pierre Koch, Prof. Dr. Stefan Laufer, Prof. Dr. Stefan Knapp, Prof. Dr. Dirk Trauner. First published: 03 June 2021. https://doi.org/10.1002/ange.202103767. Citations: 2. PDF. Tools. Share. Get access to the full version of this article.
