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  1. jmsgr.tamhsc.edu › apolipoproteine-as-a-potential-therapeutic-target-to-alterApolipoproteinE as a Potential Therapeutic Target to Alter TBI...

    Hace 2 días · Upon post mortem study, AD is characterized by presence of amyloid B plaques which have been hypothesized to contribute to neuroinflammation 2. Traumatic brain injuries (TBI) on the other hand have a wide range of both severity and cause, all of which lead to neuroinflammation. A post mortem study showed that ½ of TBI had increased amyloid ...

  2. www.nature.com › articles › s41419/024/06742-2The amyloid precursor protein and its derived fragments ... -...

    Hace 2 días · Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer’s disease (AD) related molecular actors including amyloid beta (Aβ) and recently the amyloid ...

  3. alz-journals.onlinelibrary.wiley.com › doi › 10Advancements in dementia research, diagnostics, and care in Latin...

    Hace 3 días · Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association; Alzheimer’s ... 52 Post mortem analyses of the frontal cortex of AD patients also showed differences in APOE gene expression based on diverse ancestral backgrounds. 53 Ongoing work involves studying the role of ancestry on AD risk from different genes in Peru ...

  4. medicalxpress.com › news › 2024-05-evidence-neuronal-mechanism-alzheimer-diseaseResearchers examine evidence for a novel neuronal mechanism...

    Hace 3 días · Researchers examine evidence for a novel neuronal mechanism driving Alzheimer's disease. Overview of the processes by which T14 may drive Alzheimer's disease. Credit: Alzheimer's & Dementia (2024 ...

  5. knowridge.com › 2024 › 05Research finds potential early biomarker for Alzheimer’s disease

    Hace 3 días · The study found that increased PHGDH levels in Alzheimer’s patients suggest a higher rate of serine production in the brain. The research team analyzed genetic data from post-mortem human ...

  6. onlinelibrary.wiley.com › doi › fullRegulation of mitochondrial dysfunction by estrogens and estrogen...

    Hace 3 días · In post-mortem brain samples from individuals with AD, a significant decrease in the levels of mitochondrial fusion proteins MFN1, MFN2 and OPA1 has been observed in the frontal cortex. Conversely, substantial increases in the levels of DRP1 and Fis1 32 suggest a shift towards enhanced fission, leading to mitochondrial fragmentation.

  7. www.adamedtv.com › alzheimer › los-investigadores-examinan-la-evidencia-de-unLos investigadores examinan la evidencia de un nuevo mecanismo...

    Hace 2 días · Un equipo internacional de médicos y neurocientíficos ha publicado una nueva perspectiva sobre el proceso de neurodegeneración.Sus hallazgos revisan la evidencia de un mecanismo anterior al amiloide, incluido el neuroquímico clave que impulsa este proceso.. El artículo, publicado en Alzheimer’s & Dementia, se centra en un grupo selectivo de neuronas («el núcleo isodendrítico»).