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Hace 4 días · They are FIDELIO-DKD and FIGARO-DKD, which are wholly called as FIDELITY trials. A variety of mechanisms would exist for MR overactivation in diabetic patients. Especially, it can focus on post translation of MR modifications and O-linked N-acetylglucosamine (O-GlcNAc) modification.
Hace 4 días · An analysis of the combined results of the FIDELIO and FIGARO trials was performed in the FIDELITY pooled analysis, evaluating 13,026 patients with a broad spectrum of CKD and T2D, all receiving optimized renin-angiotensin-aldosterone system (RAAS) inhibition over a median of 3 years.
Hace 5 días · Studies have indicated that low high-density lipoprotein cholesterol (HDL-C) level is an important risk factor for diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D). However ...
Hace 3 días · La actriz María Valverde (La flaqueza del bolchevique, Tres metros sobre el cielo, Tengo ganas de ti, Fuimos canciones) realiza su primer documental como directora con El canto de las manos (Song of the Hands), sobre la interpretación en lengua de signos de la ópera Fidelio, de Beethoven, en gira con su marido, el director de ...
Hace 4 días · This date may extended up to six months if a pediatric exclusivity extension is applied to the drug's patents. By analyzing the patents and regulatory protections it appears that the earliest date for generic entry will be April 12, 2029. This may change due to patent challenges or generic licensing.
Dans les études Fidelio-DKD et Figaro-DKD, la finérénone a entraîné une réduction des événements cardiovasculaires et de la progression de la maladie rénale. D’autres molécules en développement devraient venir enrichir l’arsenal thérapeutique.
Hace 5 días · La sicurezza di finerenone in pazienti con malattia renale cronica (Chronic Kidney Disease, CKD) e diabete di tipo 2 (Type 2 Diabetes, T2D) è stata valutata in 2 studi pivotal di fase III, FIDELIO-DKD (Diabetic Kidney Disease, nefropatia diabetica) e FIGARO-DKD.
