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Hace 2 días · The burgeoning field of continuous glucose monitoring (CGM) for diabetes management faces significant challenges, particularly in achieving precise and stable biosensor performance under changing environmental conditions such as varying glucose concentrations and O 2 levels. To address this, we present a novel biosensor based on the electroless coupling of glucose oxidation catalyzed by flavin ...
Hace 5 días · De novo protein design strategy. To investigate the effect of geometry on Chl−Chl coupling, we set out to design a range of C 2-symmetric dimers that hold two closely interacting Chl molecules ...
Hace 4 días · We investigated the sodium-glucose co-transporter-2 inhibitor (SGLT2i), canagliflozin (Cana), in alleviating ERS and OS in DN patients and THP-1 cells under hyperglycemic condition. A total of 120 subjects were divided into four groups, with 30 subjects in each group: healthy controls, T2DM individuals, DN patients receiving standard treatment, and those treated with Cana.
Hace 4 días · Lee et al. study the impact of oscillatory electric fields on neuronal activity across different cell types, brain regions, and species. Electric fields strongly entrain both cellular subthreshold responses and spike timing and phase, with entrainment properties being stimulation frequency and cell class specific across areas.
Hace 2 días · This state may be related to the heightened production of neutrophil extracellular traps (NETs) induced by high glucose (HG). Human cathelicidin antimicrobial peptide (LL37) is an endogenous ligand of G protein-coupled chemoattractant receptor formyl peptide receptor 2 (FPR2), expressed on neutrophils and facilitating the formation and stabilization of the structure of NETs.
Hace 4 días · In addition to glucose phosphorylation, ... The cells were incubated for 30 min at 4°C with directly coupled fluorescent antibodies and washed twice in FACS buffer before being ... was resuspended in 100 µL of KCl buffer (KCl 125 mM, EGTA 0.5 mM, succinate 5 mM, HEPES-KOH 10 mM pH 7.4, MgCl 2 4 mM, Na 2 HPO 4 5 mM) supplemented ...
Hace 2 días · First Published: 02 April 2024. This paper introduces a green and efficient method for synthesizing thiosulfonates in the aqueous phase. The approach has several benefits: it eliminates the need for catalysts and redox reagents and requires only a brief reaction time. These features give it significant economic value.
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