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Hace 1 día · Park, C. et al. Induction of G2/M cell cycle arrest and apoptosis by genistein in human bladder cancer T24 cells through inhibition of the ROS-dependent PI3k/Akt signal transduction pathway. Antioxid.
Hace 21 horas · e24122 Background: The relationship of vitamin D (VD) with cancer is controversial. Its antiproliferative function by inhibiting the cell cycle has been described, as well as its characteristics as an inhibitor of angiogenesis, inducer of apoptosis and its ability to reduce inflammation, invasion and metastasis. Deficiency of this vitamin is very prevalent, affecting 40% of the population ...
Hace 5 días · Immune cell engagers, a subclass of antibody-based constructs, consist of engineered structures designed to bridge immune effector cells to their target, thereby redirecting the immune response...
Hace 5 días · Reciprocal antagonism of PIN1-APC/C CDH1 governs mitotic protein stability and cell cycle entry. Unveiling the regulation of mitotic protein degradation is crucial for cancer therapy. Here,...
Hace 2 días · The observation that loss of either CDR2L or RPS6 causes similar effects on the cell cycle in ovarian cancer cells further supports an association between the two proteins. However, the effect of knockout of CDR2L on the cell cycle seems to be independent of changes in RPS6 expression as RPS6 was not differentially expressed following the knockout.
Hace 1 día · Cancer cells can grow uncontrollably and resist signals that normally stop cell growth [].CDKs help regulate cell growth and can pause the cell cycle if something is wrong [33, 34].CDKs regulate cell cycle progression, transcription processes, and cell proliferation [].They act as checkpoints to halt cell cycle progression in response to abnormalities during mitosis.
Hace 5 días · These results suggest that autophagy contributes to modulation of cell cycle regulators, and determines the cell cycle progression of breast cancer cells treated with D-arabinose. Collectively, our data reveal that D-arabinose can induce cell cycle arrest at the G2/M phase in an autophagy-dependent manner, indicating that enhancement ...
