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Hace 2 días · Strength of selection estimated as the density of missense mutations relative to the density of silent mutations showed only a weak correlation with tumor mutation burden.
Hace 5 días · Our results highlight that spatial heterogeneity can reduce the rate at which driver mutations spread through the population and suggest that using a well-mixed model to fit data produced by a ...
Hace 4 días · Evolution refers to the changes in the genetic makeup of populations over time, while natural selection is a mechanism that drives this process by favoring traits that enhance survival and reproduction. The essay discusses how mutations, genetic drift, and gene flow contribute to evolution, with natural selection being the most visible mechanism.
Hace 2 días · Selection drives divergence between species, contributing to speciation, while simultaneously favoring extensive diversity that is maintained across populations within a species.
Hace 1 día · Mutation is the ultimate source of all genetic variation, providing the raw material on which evolutionary forces such as natural selection can act. Mutation can result in many different types of change in sequences. Mutations in genes can have no effect, alter the product of a gene, or prevent the gene from functioning properly or ...
Hace 2 días · It is commonly thought that the long-term advantage of meiotic recombination is to dissipate genetic linkage, allowing natural selection to act independently on different loci. ... I directly derive the DFE from a gene's evolutionary history (shaped by mutation, selection, drift and gBGC) under empirical fitness landscapes.
Hace 5 días · A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to ionizing radiation, exposure to chemicals called mutagens, or infection by viruses.
