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Hace 2 días · A) Biopsy (H&E, ×400): Bone marrow shows gelatinous transformation and decrease in trilineage hematopoiesis. B) Biopsy (Alcian blue, ×400): Stain highlights gelatinous transformation. C) Bone marrow aspirate (Prussian blue, ×1000): Smear shows ring sideroblasts with iron granules encircling the nucleus of nucleated red blood cells.
Hace 4 días · The diagnosis of primary breast MZL was favored over LPL due to the absence of common LPL- associated symptoms such as bone marrow involvement.
Hace 4 días · Bone marrow biopsy revealed trilineage hematopoiesis, many hypo-or mono-lobated dysplastic megakaryocytes and less than 5% blasts. Cytogenetics/FISH unveiled 5q deletion, 20q deletion and trisomy 8. Mutation in the U2AF1 gene at S34 hotpot is detected by next-generation sequencing.
Hace 4 días · In contrast, bone marrow-derived MSCs exhibited no significant difference in mineralization and downregulated osteogenic genes following PDGF-BB treatment, whereas adipose-derived stromal/stem cells displayed increased calcium production per cell and upregulated osteogenic genes under identical PDGF-BB conditions [4, 13].
Hace 5 días · Marrow biopsy. Non-caseating granuloma in marrow. The causes of granulomas in marrow are numerous but fall into five major categories: infection, neoplasm, drug effect, connective tissue diseases, and sarcoidosis.
Hace 4 días · Several studies have highlighted the PET/CT advantages, in comparison with conventional imaging methods (MRI, CT and scintigraphy), in the detection of both bone and lymphatic metastases. PET/CT and other conventional imaging methods can detect practically 100% of the primary tumors.
Hace 1 día · Classify the primary bone marrow disorders. Explain the pathogenesis of aplastic anemia and the principles underlying its treatment. It is clear from the information presented in Chapter 2 that the regulated production of circulating blood cells depends on the presence of an adequate number of functional multipotent hematopoietic ...
