Resultado de búsqueda
Hace 2 días · The p53 family remains a captivating focus of an extensive number of current studies. Accumulating evidence indicates that p53 abnormalities rank among the most prevalent in cancer. Given the numerous existing studies, which mostly focus on the mutations, expression profiles, and functional perturbations exhibited by members of the p53 family across diverse malignancies, this review will ...
Hace 4 días · Lim et al. show that ASS1, silenced in many cancer types, is a metabolic checkpoint that, following DNA damage, halts cell cycle progression by restricting nucleotide synthesis and p53-related ...
Hace 3 días · Cuando un gen supresor de tumores es inactivado por una mutación, la proteína supresora no se produce o no funciona correctamente, y como resultado, puede producirse división celular en forma descontrolada. Dichas mutaciones pueden contribuir al desarrollo del cáncer.
Hace 1 día · Scientists describe the role of a p53 target gene in lymphoma and lung cancer development. Nov 30, 2020. Genetic signature may predict response to immunotherapy for non-small cell lung cancer.
Hace 1 día · Breast cancer is one of the most common malignant tumors in women [].The incidence of breast cancer accounts for more than 11.6% of female tumors, which is second only to uterine cancer in women [].Surgery, radiotherapy and chemotherapy are still the main therapy methods for breast cancer, while they are only suitable for patients in early stage, and have the limitations of easy recurrence and ...
Hace 4 días · Interestingly, p53 as a crucial metabolic regulator can inhibit glycolysis and switch the metabolic pathway into OXPHOS in cancer cells, facilitating cuproptosis. Moreover, p53 is known to regulate the biogenesis of iron-sulfur clusters and the copper chelator, namely GSH, further emphasizing the role of this tumor suppressor as an intermediate node between apoptosis and cuproptosis [ 102 ].
Hace 4 días · The p53 protein, often referred to as the "guardian of the genome," plays a crucial role in regulating cell division and maintaining genetic stability. Mutations or malfunctions in the p53 pathway are frequently associated with various cancers, making it a focal point in cancer research.To address these challenges, scientists have developed p53 modulators—compounds that can influence p53 ...
