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The integration of rituximab (R) into cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) by Coiffier and colleagues was the first, and last, successful modification of this backbone regimen, which has endured now for almost 20 years. Countless attempts to redefine R-CHOP for patients with diffuse large B-cell lymphoma (DLBCL) have migrated from a focus on dose-intense and dose ...
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22 de ene. de 2018 · Purpose SWOG S0016 was a phase III randomized study that compared the safety and efficacy of R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) with CHOP-RIT (CHOP followed by consolidation with iodine-133–tositumomab radioimmunotherapy) for previously untreated patients with follicular lymphoma. Understanding the long-term outcome of patients provides a ...
2 de dic. de 2016 · Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma, representing 25% of all lymphoproliferative disorders. 1 Despite its aggressive disease course, ∼50% to 70% of patients may be cured by current standard of care consisting of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy. 2 Nevertheless, R-CHOP is found to be inadequate in 30% ...
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2 de dic. de 2016 · CALGB/Alliance undertook a phase III randomized study to compare R-CHOP and DA-EPOCH-R in DLBCL and specifically within the GCB and ABC subtypes. Methods: Patients had stage II or higher newly diagnosed DLBCL, age ≥ 18 years and were HIV negative. Subjects were randomized 1:1 to receive R-CHOP or DA-EPOCH-R as previously published.
Another one of these? Really? Makes you wonder what ol’ Henry was like before hubris got to him. Well, it’s hardly surprising. A man gets to a certain point and he thinks that he is owed something. Enough years in the vanity press game and even you might start thinking that it’s real.This collection of one hundred pieces of writing represents years five and six of Henry’s employment at ...
