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27 de nov. de 2023 · We propose two analytical relationships between affinity and opinion change. The first one focuses on value homophily, while the second one incorporates affinity in opinion dynamics. Three analytical test models are derived based on these relationships: the value homophily model, the temporal evolution of opinion summation, and the evolution of opinion difference between two individuals.
6 de dic. de 2023 · Binding affinity is a vital parameter in all industries that work with biomolecules. Specificity and selectivity of binding defines how the biomolecule will interact with its surroundings. For example, novel immunotherapy drugs for cancer must both be tested for their ability to bind and neutralise cancer cells as well as their potential to bind to healthy cells and cause side effects.
1 de jun. de 2017 · In this review, we focus on protein–protein docking and binding affinity. We survey the development of algorithms for predicting the three-dimensional structures of protein–protein complexes and estimating the binding affinities of complexes and their mutants. The major contents of the review are illustrated in Figure 1.
16 de oct. de 2014 · Slightly lower AUC values are obtained when distinguishing between medium- and low-affinity complexes (Figure 4, green curves). However, worse results are obtained when distinguishing high-affinity complexes from medium-affinity complexes, pointing to apparent similarity of these two groups ( Figure 4 , blue curves).
IC 50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50%. [1] The biological component could be an enzyme, cell, cell receptor or microbe. IC 50 values are typically expressed as molar concentration .
29 de may. de 2023 · A lower K m value indicates a higher enzyme affinity towards the substrate. In comparison, a higher K m value indicates lower enzymatic affinity towards substrate (Figure 2). Figure 2: Graph showing relation between the rate of reaction and substrate amount. Image Source: Maria Victoria Gonzaga of Biology Online.
7 de jul. de 2021 · With a recent shift toward the use of machine-learning and deep-learning based methods in the field of structural biology, ... (SM_File3). Binding affinity values were obtained from the RCSB database and protein chain-ligand pairs with corresponding binding affinity as 0 were discarded to reduce statistical errors.
