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16 de nov. de 2013 · The Bacillus . Mtb is a slow growing mycobacteria with a doubling time of 12–24 h under optimal conditions. A major feature of Mtb is the peculiar cell wall structure, that provides an exceptionally strong impermeable barrier to noxious compounds and drugs and that plays a fundamental role in virulence. The classical view of the mycobacterial cell wall structure has been revised thanks to ...
15 de dic. de 2016 · ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor. ... Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall. Bioorganic and Medicinal Chemistry Letters 14, 3559–3562.
9 de oct. de 2017 · The impact of the absence of glycopeptidolipids on the ultrastructure, cell surface and cell wall properties, and phagocytosis of Mycobacterium smegmatis. Microbiology 148 , 3089–3100 (2002).
The cell wall structure of Mycobacterium tuberculosis deserves special attention because it is unique among procaryotes, and it is a major determinant of virulence for the bacterium. The cell wall complex contains peptidoglycan , but otherwise it is composed of complex lipids.
5 de may. de 2020 · Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the leading cause of death from an infectious disease, with a mortality rate of over a million people per year.This pathogen's remarkable resilience and infectivity is largely due to its unique waxy cell envelope, 40% of which comprises complex lipids.
Disruption of the cell wall structure can enhance the entry of other TB drugs, resulting in a more potent chemotherapy. More importantly, inhibition of cell wall components can lead to mycobacterial cell death. The complexity of the mycobacterial cell wall offers numerous opportunities to develop drugs to eradicate Mycobacterium tuberculosis ...
Mycobacterium tuberculosis possesses a cell wall dominated by covalently linked mycolic acids, d-arabino-d-galactan, and peptidoglycan (mAGP), the mycolic acids of which are complemented by glycolipids such as α,α′-trehalose dimycolate (TDM, cord factor) and α,α′-trehalose monomycolate (TMM) ().This mycolic acid–based permeability barrier shields the organism from environmental ...
