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The system is therefore sometimes known as the Singh-Vaughan Williams classification. The five main classes in the Vaughan Williams classification of antiarrhythmic agents are: Class I agents interfere with the sodium (Na + ) channel.
28 de feb. de 2024 · Last Update: February 28, 2024. Antiarrhythmic medications play a pivotal role in managing various cardiac rhythm disorders, and their classification under the Vaughan-Williams system serves as a cornerstone for understanding their diverse mechanisms of action.
Although different classification schemes have been proposed, the first scheme (Vaughan-Williams) is still the one that most physicians use when speaking of antiarrhythmic drugs. The following table shows the classic Vaughan-Williams classification and the basic mechanism of action associated with each class.
23 de oct. de 2018 · SYSTEMATIC REVIEW. Modernized Classification of Cardiac Antiarrhythmic Drugs. BACKGROUND: Among his major cardiac electrophysiological contributions, Miles Vaughan Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central to their clinical use.
The Vaughan Williams scheme, for all its limitations in light of subsequent developments in the cardiac electrophysiological field, thus remains the most useful, clinically and pedagogically popular approach to categorizing antiarrhythmic drugs.
4 de nov. de 1999 · Despite important and well-recognized limitations, antiarrhythmic drug classification is still widely used. In particularly broad use is the system developed by Singh and Vaughan Williams in the early 1970s and subsequently modified by Singh and Hauswirth and by Harrison.
4 de nov. de 1999 · In particularly broad use is the system developed by Singh and Vaughan Williams in the early 1970s and subsequently modified by Singh and Hauswirth and by Harrison. This classification divides drug actions into class I for sodium-channel blockade (with subclasses IA, IB and IC), class II for adrenergic antagonism, class III for ...
