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  1. pubmed.ncbi.nlm.nih.gov › 32872311CRISPR-Cas9 DNA Base-Editing and Prime-Editing - PubMed

    28 de ago. de 2020 · In this review, we describe the development of various base-editors, assess their technical advantages and limitations, and discuss their therapeutic potential to treat debilitating human diseases. Keywords: CRISPR/Cas9; adeno-associated vector; base-editing; gene therapy; genome engineering; prime-editing.

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      In this review, we describe the development of various...

  2. www.researchgate.net › 343959315_Crispr-cas9_dna_base-editing_and_prime-editingCrispr-cas9 dna base-editing and prime-editing - ResearchGate

    28 de ago. de 2020 · Crispr-cas9 dna base-editing and prime-editing. August 2020. International Journal of Molecular Sciences 21 (17):6240. DOI: 10.3390/ijms21176240. License. CC BY 4.0. Authors: Ariel...

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  4. doaj.org › article › 0c9c3a3bc3164205ab10ef85a66b19aaCRISPR-Cas9 DNA Base-Editing and Prime-Editing – DOAJ

    CRISPR-Cas9 DNA Base-Editing and Prime-Editing. Ariel Kantor, Michelle E. McClements, Robert E. MacLaren. Affiliations. DOI. https://doi.org/10.3390/ijms21176240. Journal volume & issue. Vol. 21, no. 17. p. 6240. Abstract. Read online. Many genetic diseases and undesirable traits are due to base-pair alterations in genomic DNA.

  5. www.nature.com › articles › s41434/021/00263-9Prime editing – an update on the field | Gene Therapy - Nature

    24 de may. de 2021 · Prime editing has just two components, a Cas9 nickase fused to a modified reverse-transcriptase (referred to as PE2) and a multifunctional prime editing guide RNA (pegRNA). 1 The...

  6. www.nature.com › articles › s41576/022/00541-1Prime editing for precise and highly versatile genome...

    7 de nov. de 2022 · Prime editors canonically use a Cas9 nickase that cuts only the non-complementary strand. Red DNA represents precisely edited sequence, and black DNA represents undesired outcomes. Blue...

  7. www.nature.com › articles › s41587/020/0561-9Genome editing with CRISPR–Cas nucleases, base editors ... -...

    22 de jun. de 2020 · Four classes of CRISPR-based genome editing agents are nucleases, base editors, transposases/recombinases and prime editors. Examples of starting substrates and edited products are...