Resultado de búsqueda
8 de jul. de 2023 · Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants. Aihua Hao, Wenping Song, Cheng Li, Xiang Zhang, Chao Tu, Xun Wang, Pengfei Wang, Yanling Wu, Tianlei...
3 de abr. de 2020 · CR3022 targets a highly conserved epitope, distal from the receptor binding site, that enables cross-reactive binding between SARS-CoV-2 and SARS-CoV. Structural modeling further demonstrates that the binding epitope can only be accessed by CR3022 when at least two RBDs on the trimeric S protein are in the “up” conformation and ...
5 de may. de 2020 · Our study provides insight into how SARS-CoV-2 can be targeted by the humoral immune response, and it reveals a conserved, but cryptic, epitope shared between SARS-CoV-2 and SARS-CoV.
12 de oct. de 2023 · We identified a nine amino acid epitope, termed M-SL9, that drives a co-immunodominant, cytolytic CD8 T cell response that is unconventional in two major ways: first, it is presented by Qa-1, and...
24 de feb. de 2023 · Cryptic peptides are defined as those that are processed and presented from a native antigen inefficiently and at insufficient levels to induce central tolerance under physiologic conditions 9,...
8 de may. de 2020 · CR3022 targets a highly conserved epitope, distal from the receptor binding site, that enables cross-reactive binding between SARS-CoV-2 and SARS-CoV. Structural modeling further demonstrates that the binding epitope can only be accessed by CR3022 when at least two RBDs on the trimeric S protein are in the "up" conformation and ...
15 de may. de 2016 · Optimized cryptic peptides are recognized by the immune system as non-self because they target self-cryptic peptides that escape self-tolerance; in addition they are strongly immunogenic because their sequence is modified in order to enhance their affinity for the HLA molecule.
