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30 de nov. de 2015 · β-Blockers are less effective in reducing central than peripheral systolic blood pressure. This effect is less pronounced with vasodilating than with nonvasodilating β-blockers, although the difference is mostly explained by a lower reduction in heart rate with the former.
9 de jun. de 2021 · Nebivolol, a third-generation β-blocker, has additional vasodilator actions, related to enhanced release of NO in the vascular wall, compared with bisoprolol, a second-generation agent. The additional NO-releasing effect of nebivolol may underlie reports of improvements in erectile function in patients receiving this agent.
29 de mar. de 2021 · Several meta-analyses have concluded that efficacy of β-blockers in hypertension is inferior compared with other classes of antihypertensive drugs: ACE (angiotensin-converting enzyme) inhibitors, angiotensin receptor blockers (ARBs), calcium-channel blockers (CCBs), and thiazide or thiazide-like diuretics (TDs). 6–10 As such, the American Colleg...
To date, 3 generations of drugs have been released: nonselective β-blockers, cardioselective β-blockers (selective β 1 -antagonists), and a third generation of these drugs able to block β 1 together with extra vasodilation activity (also called vasodilating β-blockers) either by blocking α 1 - or by activating β 3 -AR.
The newer generation of β-blockers, namely carvedilol and nebivolol, is changing the manner in which β-blockers are viewed in hypertension management. Their ability to inhibit A1 adrenoreceptors and influence nitric oxide leads to vasodilation, which traditional β-blockers fail to do.
22 de abr. de 2015 · Vasodilators have been shown to be of particular benefit in both blood pressure control and other cardiometabolic components with limited disturbance in metabolic parameters. Nebivolol, a third-generation beta-blocker (BB), acts by increasing nitric oxide (NO) bioavailability.
10 de abr. de 2024 · β-blockers are a diverse class of drugs, differentiated by varying (or absent) selectivity for blockade of β 1 - vs. β 2-adrenoceptors, intrinsic sympathomimetic activity at either or both of these receptors, the presence or absence of additional vasodilator mechanisms (actions of β 3-adrenoceptors that stimulate nitric oxide ...
