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20 Jan 2023. Vol 379, Issue 6629. DOI: 10.1126/science.add8643. A decade of CRISPR. In the decade since the publication of CRISPR-Cas9 as a genome-editing technology, the CRISPR toolbox and its applications have profoundly changed basic and applied biological research.
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ificity and efficacy of CRISPR-Cas9, such gene knockouts are...
- Btg1 Mutation Yields Supercompetitive B Cells Primed for Malignant Transformation
Conditional Btg1 WTKI mice (R26 lsl.Btg1wt) were generated...
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15 de may. de 2018 · CRISPR-Cas9 is no longer just a gene-editing tool; the application areas of catalytically impaired inactive Cas9, including gene regulation, epigenetic editing, chromatin engineering, and...
28 de nov. de 2014 · CRISPR-Cas9 is having a major impact on functional genomics conducted in experimental systems. Its application in genome-wide studies will enable large-scale screening for drug targets and other phenotypes and will facilitate the generation of engineered animal models that will benefit pharmacological studies and the understanding of ...
7 de oct. de 2020 · NEWS. 07 October 2020. Pioneers of revolutionary CRISPR gene editing win chemistry Nobel. Emmanuelle Charpentier and Jennifer Doudna share the award for developing the precise genome-editing...
16 de ene. de 2023 · CRISPR/ Cas9 is a highly effective gene-editing tool that is widely used in the scientific community. 6 The CRISPR/Cas9 system evolved naturally in bacteria and archaea as a defense...
31 de ago. de 2018 · CRISPR-Cas guides the future of genetic engineering. Gavin J. Knott and Jennifer A. Doudna Authors Info & Affiliations. Science. 31 Aug 2018. Vol 361, Issue 6405. pp. 866 - 869. DOI: 10.1126/science.aat5011. Abstract. The diversity, modularity, and efficacy of CRISPR-Cas systems are driving a biotechnological revolution.
1 de feb. de 2024 · The CRISPR-Cas9 technology represents a revolutionary breakthrough in genome editing, powered by the coordinated action of its essential components – the guide RNA (gRNA) and Cas9 endonuclease. The gRNA, a succinct 20-nucleotide sequence, demonstrates high gene specificity by binding to the target DNA through the protospacer ...
