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16 de abr. de 2020 · GLUTs are divided into two structurally and functionally distinct types: (i) GLUTs, which operate by facilitated diffusion 1 , 2 ; and (ii) sodium–glucose cotransporters (SGLTs), which actively transport glucose against the concentration gradient by coupling with sodium 3 , 4 .
INTRODUCTION. Sodium-glucose cotransporter (SGLT) activity mediates apical sodium and glucose transport across cell membranes. Cotransport is driven by active sodium extrusion by the basolateral sodium/potassium-ATPase, thus facilitating glucose uptake against an intracellular up-hill gradient.
Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST).
10 de feb. de 2011 · For example, the Na + /glucose cotransporter (SGLT1), found in the small intestine and kidney proximal tubules, simultaneously transports 2 Na + ions and 1 glucose molecule into the cell across the plasma membrane.
Furthermore, enhanced glucose reabsorption is coupled to sodium retention through the sodium-glucose cotransporter SGLT2, which induces secondary deleterious effects. As a consequence, SGLT2 inhibitors are new anti-hyperglycemic drugs that can protect the kidneys and heart from failing.
The low-affinity SGLT transporter had an apparent coupling stoichiometry of 1 Na:1 sugar, whereas for the high-affinity transporter, it was 2 Na:1 sugar. The low-affinity transporter became to be known as SGLT2, and the high-affinity transporter was determined to be SGLT1 .
8 de dic. de 2021 · SGLT1, the first member of the large sodium–solute symporter (SSS) family 2 to be identified, is a high-affinity, low-capacity glucose transporter with an apparent 2 Na +:1 sugar coupling ...
