Resultado de búsqueda
16 de abr. de 2020 · GLUTs are divided into two structurally and functionally distinct types: (i) GLUTs, which operate by facilitated diffusion 1 , 2 ; and (ii) sodium–glucose cotransporters (SGLTs), which actively transport glucose against the concentration gradient by coupling with sodium 3 , 4 .
INTRODUCTION. Sodium-glucose cotransporter (SGLT) activity mediates apical sodium and glucose transport across cell membranes. Cotransport is driven by active sodium extrusion by the basolateral sodium/potassium-ATPase, thus facilitating glucose uptake against an intracellular up-hill gradient.
Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST).
The low-affinity SGLT transporter had an apparent coupling stoichiometry of 1 Na:1 sugar, whereas for the high-affinity transporter, it was 2 Na:1 sugar. The low-affinity transporter became to be known as SGLT2, and the high-affinity transporter was determined to be SGLT1 .
8 de dic. de 2021 · SGLT1, the first member of the large sodium–solute symporter (SSS) family 2 to be identified, is a high-affinity, low-capacity glucose transporter with an apparent 2 Na +:1 sugar coupling ...
Na + /glucose cotransporters (SGLTs) are responsible for the “secondary-active” transport of glucose and other substrates across cellular membranes. They concentrate glucose inside the cell using electrochemical energy from the transmembrane Na + gradient, employing an alternating access cotransport mechanism.
7 de ago. de 2020 · Inhibition of SGLT2-mediated Na +-coupled glucose transport significantly increases NaCl exposure at the macula densa. This is followed by increased transport activity of SLC12A1 (NKCC2) in macula densa cells.
